Effectiveness of increasing the frequency of posaconazole syrup administration to achieve optimal plasma concentrations in patients with haematological malignancy
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- 作者：Wan Beom Parka ; 1 ; Joo-Youn Chob ; 1 ; Sang-In Parkb ; Eun Jung Kima ; Seonghae Yoonb ; Seo Hyun Yoonb ; Jeong-Ok Leea ; Youngil Koha ; Kyoung-Ho Songa ; Pyoeng Gyun Choea ; Kyung-Sang Yub ; Eu suk Kima ; Su Mi Banga ; Nam Joong Kima ; Inho Kima ; Myoung-don Oha ; Hong Bin Kima ; hbkimmd@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Sang Hoon Songc ; cloak21@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Posaconazole ; Syrup ; Leukaemia ; Therapeutic drug monitoring ; Concentration
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：48
- 期：1
- 页码：106-110
- 全文大小：653 K
文摘
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Increasing the frequency of posaconazole syrup is effective for adjusting drug levels.
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Optimal drug levels are not achieved when steady-state level is <200 ng/mL.
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In only 5.3% (6/114), drug levels remained suboptimal despite dose adjustment.