The mGluR5 antagonist MPEP suppresses the expression and reinstatement, but not the acquisition, of the ethanol-conditioned place preference in mice
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- 作者：Jun-Yeob Leea ; g ; Eun Sang Choeb ; Chae Ha Yangc ; Kwang H. Choid ; Jae Hoon Cheonge ; Choon-Gon Jangf ; Joung-Wook Seoa ; jwseo@kitox.re.kr" class="auth_mail" title="E-mail the corresponding author ; Seong Shoon Yoona ; ssyoon@kitox.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：mGluR5 ; MPEP ; Conditioned place preference ; Rewarding effects ; Mice ; Ethanol
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：33-38
- 全文大小：658 K
文摘
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Effects of MPEP on the rewarding effects of ethanol were examined.
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MPEP dose-dependently reduced the expression and reinstatement of ethanol CPP.
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MPEP did not affect the acquisition of ethanol CPP.
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Blockade of the mGluR5 receptor may play several distinct roles during the development of ethanol addiction.