Peroxiredoxin 5 (Prx5) decreases LPS-induced microglial activation through regulation of Ca2+/calcineurin-Drp1-dependent mitochondrial fission
详细信息 查看全文
- 作者：Junghyung Parka ; b ; Hoonsung Choic ; Bokyung Kima ; b ; Unbin Chaea ; b ; Dong Gil Leea ; b ; Sang-Rae Leed ; Seunghoon Leec ; Hyun-Shik Leea ; b ; Dong-Seok Leea ; b ; lee1@knu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：TLR4 ; Toll-like receptor 4 ; NADPH oxidase ; nicotinamide adenine dinucleotide phosphate oxidase ; Cys ; cysteine ; Drp1 ; dynamin-related protein 1 ; Fis1 ; mitochondrial fission 1 ; Mfn1/2 ; mitofusin 1 and 2 ; Opa1 ; optic atrophy protein 1 ; Ser ; serine ; cAMP ; Cyclic adenosine monophosphate ; PKA ; Protein kinase A ; NAC ; N-acetyl-l-cysteine ; TBST ; Tris-buffered saline Tween 20 ; FK506 ; tacrolimus ; A23187 ; calcimycin ; NFAT ; nuclear factor of activated T-cells ; PGAM5 ; phosphoglycerate mutase family member 5
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：392-404
- 全文大小：3480 K
文摘
- •
Prx5 ameliorated the pro-inflammatory response through regulation of MAPK and NF-κB.
- •
Prx5 suppresses excessive mitochondrial fission by eliminating ROS.
- •
De-phosphorylation of Drp1 by Ca2+/calcineurin governs mitochondrial morphology.
- •
Prx5 modulated increase in intracellular Ca2+ and calcineurin activation.
- •
Prx5 regulated Nox-derived and cytosolic ROS in activated microglia cells.