We developed a bionano hybrid material composed of recombinant azurin (Az) and CdSe-ZnS quantum dot to perform as a resistive random access memory (ReRAM) device. Site specific amino acid sequences were introduced in Az to bind with the surface of CdSe-ZnS nanoparticle allowing the formation of a hybrid and voltage-driven switching enabled to develop a resistive random access memory (ReRAM) device. The developed device shown good stability and repeatability and operates at low voltages thus makes it promising candidate for future memory device applications.