Comparison of bare and amino modified mesoporous silica@poly(ethyleneimine)s xerogel as indomethacin carrier: Superiority of amino modification
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- 作者：Jing Li ; Lu Xu ; Hongyu Wang ; Baixue Yang ; Hongzhuo Liu ; Weisan Pan ; Sanming Li ; li_sanming2013@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mesoporous silica ; Biomimetic synthesis ; Amino modification ; Indomethacin ; Insoluble drug
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：710-716
- 全文大小：1431 K
文摘
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Amino modified mesoporous silica xerogel was biomimetic synthesized (B-AMSX).
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Indomethacin (IMC) loading capacity was improved using B-AMSX compared to B-MSX.
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B-AMSX and B-MSX enhanced IMC dissolution due to crystalline conversion effect.
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IMC released faster from B-AMSX than B-MSX due to larger pore diameter of IMC-AMSX.