Elevated serum levels of thioredoxin in patients with acute exacerbation of asthma

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• 作者：Yamada ; Yoshiyuki ; Nakamura ; Hajime ; Adachi ; Tetsuya ; Sannohe ; Satoshi ; Oyamada ; Hajime ; Kayaba ; Hiroyuki ; et. al.
• 关键词：Thioredoxin/adult T-cell leukemia-derived factor ; Oxidative stress ; Bronchial asthma ; Acute exacerbation
• 刊名：Immunology Letters
• 出版年：2003
• 出版时间：April 3, 2003
• 年：2003
• 卷：86
• 期：2
• 页码：199-205
• 全文大小：160 K

文摘

The pathogenesis of bronchial asthma is chronic airway inflammation caused by immune cells such as T lymphocytes and eosinophils. Eosinophils release cytotoxic products including reactive oxygen species at the site of inflammation, leading to epithelial damage. Human thioredoxin (TRX), a redox-regulating protein with antioxidant activity, is induced and secreted from cells by oxidative stress. This study was undertaken to investigate the clinical significance of TRX in the pathogenesis of asthma. We collected blood samples from 48 patients with bronchial asthma with or without attack, and measured serum ECP and pulmonary function as well as serum TRX. The serum TRX levels in patients with asthma were significantly increased in patients with mild (34.63 [28.40–42.73] ng/ml, medians with 25 and 75 % interquartiles, P