Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions
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- 作者：Matthieu Chavent
- 刊名：Structure
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：24
- 期：2
- 页码：337-347
- 全文大小：3979 K
文摘
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- <p id="p0010">EphA2 receptor ectodomain mainly interacts with lipid bilayers via its FN2 domainp>
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- <p id="p0015">Anionic lipids are recruited by positively charged residues in FN2p>
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- <p id="p0020">Mutations K441E and R443E abolish the specific binding of FN2 to anionic lipidsp>
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- <p id="p0025">The FN2-bilayer interaction orients the EphA2 ectodomain relative to a membranep>