Bioactive components from the heartwood of Pterocarpus santalinus

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• 作者：Shou-Fang Wup>ap> ; Tsong-Long Hwangp>bp> ; Shu-Li Chenp>ap> ; Chin-Chung Wup>ap> ; Emika Ohkoship>cp> ; Kuo-Hsiung Leep>cp>p> ; p>p>dp> ; Fang-Rong Changp>ap>p> ; p>p>ep>p> ; p>p>fp>p> ; p>p>aaronfrc@kmu.edu.tw"" rel=""nofollowp> ; Yang-Chang Wup>ap>p> ; p>p>gp>p> ; p>p>hp>p> ; p>p>yachwu@mail.cmu.edu.tw"" rel=""nofollowp>p> ; p>p>yachwu@kmu.edu.tw"" rel=""nofollowp>
• 关键词：Pterocarpus santalinus ; Pterolinus K ; Pterolinus L ; Phenanthrenedione ; Chalcone ; Anti-inflammatory ; Cytotoxicity
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2011
• 出版时间：15 September 2011
• 年：2011
• 卷：21
• 期：18
• 页码：5630-5632
• 全文大小：209 K

文摘

One new phenanthrenedione, pterolinus K (1), and one new chalcone, pterolinus L (2) were isolated from the heartwood extract of Pterocarpus santalinus. The structures were elucidated by spectroscopic methods. Both 1 and 2 showed inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC₅₀ value of 4.24 and 0.95 μM, and compound 1 also inhibited superoxide anion generation with IC₅₀ value of 0.99 μM. In addition, compound 1 showed selective cytotoxicity against HepG2 with IC₅₀ value of 10.86 μM, while compound 2 showed a moderate cytotoxicity against KB with IC₅₀ values of 17.18 μM.