Topical amphotericin B in ultradeformable liposomes: Formulation, skin penetration study, antifungal and antileishmanial activity in vitro
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- 作者：Ana Paula Pereza ; Maria Julia Altubea ; Priscila Schilrreffa ; Gustavo Apezteguiaa ; Fabiana Santana Celesb ; Susana Zacchinoc ; Camila Indiani de Oliveirab ; Eder Lilia Romeroa ; Maria Jose Morillaa ; jmorilla@unq.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Flexible liposomes ; Skin delivery ; Candida spp. ; Leishmania braziliensis ; Nanomedicine
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：139
- 期：Complete
- 页码：190-198
- 全文大小：855 K
文摘
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Ultradeformable liposomes containing amphotericin B (AmB-UDL) were prepared to enhance AmB topical delivery for treatment of cutaneous fungal infections and leishmaniasis.
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Fungal strains (albicans and non-albicans Candida ATCC strains and clinical isolates of C. albicans) were more sensitive than mammal cells to AmB-UDL.
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AmB-UDL showed 100 and 75% anti-promastigote and anti-amastigote activity on L. braziliensis.
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Total accumulation of AmB in skin was 40 times higher when applied as AmB-UDL than as AmBisome.