Antidepressant drugs and memory: Insights from animal studies
详细信息 查看全文
- 作者：Santiago Monleó ; n ; Concepció ; n Vinader-Caerols ; M. Carmen Arenas ; André ; s Parra
- 关键词：Antidepressants ; Memory ; Learning ; Rats ; Mice
- 刊名：European Neuropsychopharmacology
- 出版年：2008
- 出版时间：April 2008
- 年：2008
- 卷：18
- 期：4
- 页码：235-248
- 全文大小：312 K
文摘
This is a selective review of the literature concerning the effects of antidepressant drugs on animal memory, which was performed with the aid of the PubMed database. Monoamine oxidase inhibitors tend to either have no effect on memory or result in its improvement. Studies with cyclic antidepressants have reported no effect or, more often, memory impairments. Pre-training administration of selective serotonin reuptake inhibitors (SSRIs) has been shown to have either no effect on memory or undermine it (with some isolated exceptions, in which improvements have been recorded), while post-training administration of SSRIs has been demonstrated to improve memory or have no effect. A small group formed by the remaining antidepressants has been shown to improve memory, with the exception of trazodone, which impairs memory. These findings are discussed in the light of knowledge regarding the actions of antidepressants on several neurotransmission systems. The possibility that the effects of antidepressants on memory are the core of the therapeutic effects of these drugs is also considered.