MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease
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- 作者：Shelly C. Lua ; José ; M. Matob ; Cristina Espinosa-Diezc ; Santiago Lamasd ; slamas@cbm.csic.es" class="auth_mail" title="E-mail the corresponding author
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：66-72
- 全文大小：664 K
文摘
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The route of glutathione synthesis is critical for antioxidant defense.
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Methionine metabolism is essentially linked to glutathione synthesis.
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Several microRNAs have been identified as important regulators for both methionine metabolism and glutathione synthesis.
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These miRNAs may regulate crucial pathophysiological settings such as organ fibrosis or hepatocellular carcinoma.