Epidemiologic and Clinical Features of Other Enteric Viruses Associated with Acute Gastroenteritis in American Indian Infants

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• 作者：Lindsay Grant ; PhD ; MPH¹ ; ^{lgrant@jhsph.edu} ; Jan Vinjé ; PhD² ; Umesh Parashar ; MBBS ; MPH³ ; James Watt ; MD ; MPH¹ ; Raymond Reid ; MD ; MS¹ ; Robert Weatherholtz ; BS¹ ; Mathuram Santosham ; MD ; MPH¹ ; Jon Gentsch ; PhD² ; Katherine O&rsquo ; Brien ; MD ; MPH¹
• 关键词：AGE ; Acute gastroenteritis ; AI ; American Indian ; AN ; Alaska native ; PRV ; Pentavalent rotavirus vaccine ; RT-PCR ; Reverse transcriptase-polymerase chain reaction
• 刊名：The Journal of Pediatrics
• 出版年：2012
• 出版时间：July, 2012
• 年：2012
• 卷：161
• 期：1
• 页码：110-115.e1
• 全文大小：243 K

文摘

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Objective

To investigate the viral etiology, through the use of molecular methods, of acute gastroenteritis (AGE), which is a considerable public health burden in Native American infants.

Study design

From March 2002 through February 2004, AGE and non-diarrheal stools were collected from Navajo and White Mountain Apache infants who received placebo during a rotavirus vaccine trial. Case (n = 247) and control (n = 344) specimens were tested for enteric adenovirus, astrovirus, norovirus, rotavirus, and sapovirus with real-time polymerase chain reaction. The odds of AGE were compared with population-averaged logistic regression models.

Results

In 65 % of the cases of AGE (161/247), at least one virus was detected; norovirus (n = 80, 32 % ) and rotavirus (n = 70, 28 % ) were the most common. A virus was detected in 38 % of control specimens (132/344). Detection of ¡°any virus¡± was associated with AGE (OR = 3.22; 95 % CI, 2.11-4.91), as was detection of norovirus (OR = 2.00; 95 % CI, 1.22-3.26) and rotavirus (OR = 2.69; 95 % CI, 1.52-4.79).

Conclusion

This study highlights the significant burden of viral AGE in American Indian infants and identifies pathogen targets for future prevention efforts in this population.