Structural and rheological characterization of Scleroglucan/borax hydrogel for drug delivery

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• 作者：Coviello ; Tommasina ; Coluzzi ; Gina ; Palleschi ; Antonio ; Grassi ; Mario ; Santucci ; Eleonora ; et. al.
• 关键词：Scleroglucan ; Hydrogel characterization ; Controlled release
• 刊名：International Journal of Biological Macromolecules
• 出版年：2003
• 出版时间：September, 2003
• 年：2003
• 卷：32
• 期：3-5
• 页码：83-92
• 全文大小：251 K

文摘

The polysaccharide Scleroglucan, one of the most rigid polymers found in nature, can form a chemical/physical gel, in the presence of borax. The obtained hydrogel was loaded with three different model molecules (Theophylline, Vitamin B12 and Myoglobin) and then, after freeze-drying, was used as a matrix for tablets. The release profiles of the substances from the dosage forms were evaluated; the matrix appeared capable to modulate the diffusion of the chosen molecules, and different diffusion rates were observed, according to the different radii of the tested molecules. Interestingly, in the dissolution medium the matrix undergoes an anisotropic swelling taking place only in the axial direction, while a negligible radial variation occurs. The water uptake of the matrix occurs according to a Fickian process.