Suppression of intestinal immunity through silencing of TCTP by RNAi in transgenic silkworm, Bombyx mori
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- 作者：Cuimei Hu ; Fei Wang ; Sanyuan Ma ; Xianyang Li ; Liang Song ; Xiaoting Hua ; Qingyou Xia ; xiaqy@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BmTCTP ; translationally controlled tumor protein of silkworm ; PAMPs ; pathogen-associated molecular patterns ; PRRs ; pattern recognition receptors ; PGRPs ; peptidoglycan recognition proteins ; GNBP ; gram-negative binding protein ; AMPs ; antimicrobial peptides ; BmTCTPS ; BmTCTP-Sense ; BmTCTPA ; BmTCTP-Antisense ; WT ; wild-type ; WSSV ; white spot syndrome virus ; IBDs ; chronic inflammatory bowel diseases
- 刊名：Gene
- 出版年：2015
- 出版时间：10 December 2015
- 年：2015
- 卷：574
- 期：1
- 页码：82-87
- 全文大小：604 K
文摘
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BmTCTP RNAi silkworms were constructed successfully by transgenic technique.
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The gut AMP from BmTCTP RNAi silkworm wasn't induced after oral microbial challenge.
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Survival rates of BmTCTP RNAi silkworm larvae decreased upon bacterial infection.
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BmTCTP RNAi affected dynamics of ERK phosphorylation in silkworm midgut.