PSD-95 regulates CRFR1 localization, trafficking and β-arrestin2 recruitment
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- 作者：Henry A. Dunna ; c ; Harpreet S. Chahala ; Fabiana A. Caetanoa ; Kevin D. Holmesa ; George Y. Yuana ; Ruchi Parikha ; Bryan Heitb ; Stephen S.G. Fergusonc ; sferguso@uottawa.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; β1AR ; β1-adrenergic receptor ; CRF ; corticotropin-releasing factor ; CRFR1 ; CRF receptor 1 ; ERK1/2 ; extracellular signal-regulated kinase ; GPCR ; G protein-coupled receptor ; GRK ; G protein-coupled receptor kinase ; HA ; hemagglutinin ; HEK 293 ; human embryonic kidney 293 ; PTH1R ; parathyroid hormone 1 receptor ; MAPK ; mitogen-activated protein kinase ; PSD-95 ; postsynaptic density 95 ; PDZ ; PSD-95/Disc Large/Zona Occludens ; 5-HT2AR ; 5-HT2A receptor ; SAP97 ; synapse-associated p
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：28
- 期：5
- 页码：531-540
- 全文大小：1529 K
文摘
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CRFR1 and PSD-95 have both been linked to mental illness and psychiatric disease.
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Endogenous CRFR1 and PSD-95 interact in cortical mouse brain.
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PDZ interactions promote synaptic targeting of CRFR1 to PSD-95 compartment.
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PSD-95 suppresses CRFR1 endocytosis and βarrestin-2 recruitment.
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PSD-95 is not independently responsible for CRFR1 crosstalk with 5-HT2AR.