Dose-response characteristics of Clematis triterpenoid saponins and clematichinenoside AR in rheumatoid arthritis rats by liquid chromatography/mass spectrometry-based serum and urine metabolomics

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• 作者：Rui Li^a ; Lin-Xiu Guo^a ; Yi Li^a ; Wen-Qi Chang^a ; Jian-Qun Liu^b ; Li-Fang Liu^a ; ^{liulifang69@126.com} ; Gui-Zhong Xin^a ; ^{xingz@cpu.edu.cn}
• 关键词：Clematidis Radix et Rhizoma ; Clematis triterpenoid saponins ; Clematichinenoside AR ; Rheumatoid arthritis ; Metabolomics ; Biomarkers
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 March 2017
• 年：2017
• 卷：136
• 期：Complete
• 页码：81-91
• 全文大小：3902 K
• 卷排序：136

文摘

Metabolomics study of Clematis triterpenoid saponins (TS) and clematichinenoside AR (C-AR) on collagen-induced arthritis rat was investigated. The Clematis TS and C-AR treatment groups presented a dose-dependent reversal effect on metabolic trajectory and corresponding biomarkers. 45 potential biomarkers were identified in response to RA. Glycerophospholipid catabolism, sphingolipid metabolism, arachidonic acid metabolism were filtered out as the potential target pathways.