The effects of chemically synthesized saposin C on glucosylceramide-β-glucosidase
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- 作者：Azusa Yoneshigea ; b ; Masanaga Mutoa ; c ; Takashi Watanabea ; d ; Hironobu Hojoa ; e ; Junko Matsudaa ; f ; matsujun@med.kawasaki-m.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：4MU-Glc ; 4-methyl-umbelliferyl-β-d-glucopyranoside ; BMP ; bis(monoacylglycero)phosphate ; ERT ; enzyme replacement therapy ; GCase ; glucosylceramide-β-glucosidase ; GlcCer ; glucosylceramide ; NBD-GlcCer ; 4-nitrobenzo-2-oxa-1 ; 3-diazole labeled glucosylceramide ; SAP-C ; saposin C
- 刊名：Clinical Biochemistry
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：48
- 期：16-17
- 页码：1177-1180
- 全文大小：364 K
文摘
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Chemically synthesized saposin C enhanced imiglucerase activity.
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Chemically synthesized saposin C stabilized imiglucerase at lower concentration.
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Chemically synthesized saposin C protected imiglucerase from cathepsin D digestion.
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Saposin-C could be useful to increase ERT efficacy for Gaucher's disease.