Validation of a neuropathology score using quantitative methods to evaluate brain injury in a pig model of hypoxia ischaemia
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- 作者：Nicholas Hoquea ; 1 ; Hemmen Sabira ; 1 ; Elke Maesa ; b ; 1 ; 2 ; Sarah Bishopa ; 1 ; Marianne Thoresena ; b ; 1 ; 2 ; marianne.thoresen@bristol.ac.uk" class="auth_mail ; marianne.thoresen@medisin.uio.no" class="auth_mail
- 关键词：aEEG ; amplitude integrated electroencephalogram ; HI ; hypoxia ischaemia ; HT ; hypothermia ; NT ; normothermia
- 刊名：Journal of Neuroscience Methods
- 出版年：15 June 2014
- 年：2014
- 卷：230
- 期：Complete
- 页码：30-36
- 全文大小：1972 K
文摘
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Graded neuropathology score used in a perinatal global hypoxia-ischaemia pig model.
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Healthy neuronal cell density correlated with neuropathology score.
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Both methods detected a difference between treatment (normothermia and hypothermia).
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Our neuropathology score is a valid method to assess regional and global brain injury.