Differential gene expression in brain and peripheral tissues in depression across the life span: A review of replicated findings

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• 作者：Liliana G. Ciobanu^a ; Perminder S. Sachdev^b ; Julian N. Trollor^b ; Simone Reppermund^b ; ^c ; Anbupalam Thalamuthu^b ; Karen A. Mather^b ; Sarah Cohen-Woods^d ; Bernhard T. Baune^a ; ^{bernhard.baune@Adelaide.edu.au}
• 关键词：Depression ; Major depressive disorder ; Transcriptome ; Genome-wide differential gene expression
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：71
• 期：Complete
• 页码：281-293
• 全文大小：2347 K
• 卷排序：71

文摘

Genome-wide gene expression signature of depression identifies potential novel mechanisms and treatment targets. 57 brain and 21 peripheral DEGs are replicated at genome-wide level in depression. Functional overlap between brain and periphery links depression and CVD. Dermal fibroblasts are a promising experimental model for depression biomarker research. Gene PXMP2 is a proposed novel candidate for pathophysiology of depression.