A Functional Role for Antibodies in Tuberculosis
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- 作者：Lenette L. Lu1 ; 2 ; 11 ; Amy W. Chung1 ; 3 ; 11 ; Tracy R. Rosebrock2 ; 11 ; Musie Ghebremichael1 ; Wen Han Yu1 ; 4 ; Patricia S. Grace1 ; Matthew K. Schoen1 ; Fikadu Tafesse1 ; Constance Martin2 ; Vivian Leung2 ; Alison E. Mahan1 ; Magdalena Sips1 ; 6 ; Manu P. Kumar4 ; Jacquelynne Tedesco1 ; Hannah Robinson1 ; Elizabeth Tkachenko1 ; Monia Draghi1 ; Katherine J. Freedberg1 ; Hendrik Streeck5 ; Todd J. Suscovich1 ; Douglas A. Lauffenburger4 ; Blanca I. Restrepo7 ; Cheryl Day8 ; 9 ; 10 ; Sarah M. Fortune2 ; sfortune@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Galit Alter1 ; 12 ; galter@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：antibodies ; tuberculosis ; innate immunity ; Fc-receptors ; inflammasome
- 刊名：Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：167
- 期：2
- 页码：433-443.e14
- 全文大小：3189 K
文摘
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Individuals with latent and active TB infection have divergent humoral signatures
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Antibodies in latent TB infection have enhanced Fc effector profiles
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Antibody glycosylation patterns can discriminate between latent and active TB
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Antibodies in latent TB infection drive macrophages to kill intracellular bacteria