Tuberculosis or sarcoidosis: Opposite ends of the same disease spectrum?

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• 作者：Rupesh Agrawal^a ; ^g ; ^{rupesh_agrawal@ttsh.com.sg" class="auth_mail" title="E-mail the corresponding author} ; Ae Ra Kee^b ; ^{A0084529@u.nus.edu" class="auth_mail" title="E-mail the corresponding author} ; Leslie Ang^a ; ^{leslie.ang@mohh.com.sg" class="auth_mail" title="E-mail the corresponding author} ; Yeo Tun Hang^a ; ^{tunhang.yeo@mohh.com.sg" class="auth_mail" title="E-mail the corresponding author} ; Vishali Gupta^c ; ^{vishalisara@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author} ; Onn Min Kon^d ; ^{Onn.Kon@imperial.nhs.uk" class="auth_mail" title="E-mail the corresponding author} ; Donald Mitchell^e ; ^{Donald.mitchell@imperial.nhs.uk" class="auth_mail" title="E-mail the corresponding author} ; Manfred Zierhut^f ; ^{Manfred.Zierhut@med.uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author} ; Carlos Pavesio^g ; ^{carlos.pavesio@moorfields.nhs.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Tuberculosis ; Sarcoidosis ; Sarcoid tuberculosis (ST) ; Tuberculous sarcoid (TS)
• 刊名：Tuberculosis
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：98
• 期：Complete
• 页码：21-26
• 全文大小：828 K

文摘

Tuberculosis and sarcoidosis are chronic systemic diseases that have similar pulmonary and extra-pulmonary manifestations. Multiple studies have found an epidemiological, molecular, and immunological link between the two. It has been suggested that mycobacterium tuberculosis could be a common pathophysiologic mechanism for tuberculosis and sarcoidosis, and that both clinical entities can trigger similar immunological response in patients. Due to this close association, together with possible coexistence in the same patient, the diagnosis of one disease from another may be difficult. In our paper, we suggest that tuberculosis and sarcoidosis are two ends of the same spectrum. Given the pathophysiological and clinical link between the two, we also propose a classification system for tuberculosis and sarcoidosis: Sarcoidosis (S); Sarcoid-Tuberculous (ST); Tuberculous Sarcoid (TS) and Tuberculosis (TB). More research and clinical trials should first be done to affirm the link between the two disease entities.