Evidence that a threshold of serine/arginine-rich (SR) proteins recruits CFIm to promote rous sarcoma virus mRNA 3′ end formation
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- 作者：Stephen W. Hudson ; Lisa M. McNally ; Mark T. McNally ; mtm@mcw.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rous sarcoma virus ; SR proteins ; RNA splicing ; Polyadenylation ; 3&prime ; end processing ; CFIm
- 刊名：Virology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：498
- 期：Complete
- 页码：181-191
- 全文大小：1993 K
文摘
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At least five SRSF1 protein binding sites are required to replace the Env enhancer.
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The NRS and Env enhancer show position-dependent activation of polyadenylation.
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SR proteins promote binding of CFIm to polyadenylation substrates.
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A threshold of SR proteins are required to promote RSV polyadenylation.
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SR protein recruitment of CFIm may not be direct.