Synthetic stigmastanes with dual antiherpetic and immunomodulating activities inhibit ERK and Akt signaling pathways without binding to glucocorticoid receptors
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- 作者：Flavia M. Michelinia ; Carlos A. Buenoa ; Alejandro M. Molinarib ; Mario D. Galignianab ; Lydia R. Galagovskyc ; Laura E. Alché ; a ; Javier A. Ramí ; rezc ; jar@qo.fcen.uba.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALDO ; aldosterone ; CC ; cell control ; CC50 ; Cytotoxic Concentration 50% ; CORT ; corticosterone ; DEX ; dexamethasone ; EC50 ; Effective Concentration 50% ; GFP ; Green Fluorescent Protein ; GR ; glucocorticoid receptor ; HCLE ; Human corneal&ndash ; limbal epithelial cell line ; HSK ; herpetic stromal keratitis ; HSV-1 ; Herpes simplex virus type 1 ; IOBA-NHC ; Normal human conjunctival cell line ; m.o.i. ; multiplicity of infection ; MR ; mineralocorticoid receptor ; RSV ; Rous sarcoma virus ; SI ; Selectivity index ; 25HC
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1860
- 期：1
- 页码：129-139
- 全文大小：1529 K
文摘
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The chemical synthesis of new stigmastanes fluorinated at C-6 is reported.
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These steroidal compounds exert both immunomodulating and antiviral activities.
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They inhibit ERK and Akt signaling pathways, but do not act as glucocorticoids.
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Fluorination enhances the antiviral activity.