Characterization of sarcoplasmic reticulum Ca2+ ATPase pumps in muscle of patients with myotonic dystrophy and with hypothyroid myopathy
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- 作者：V. Guglielmia ; A. Oosterhofb ; N.C. Voermansc ; R. Cardanid ; J.P. Molenaarc ; T.H. van Kuppeveltb ; G. Meolad ; B.G. van Engelenc ; G. Tomelleria ; G. Vattemia ; gaetano.vattemi@univr.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 1 (SERCA1) ; SERCA1b ; Myotonic dystrophy ; Hypothyroid myopathy ; Brody myopathy
- 刊名：Neuromuscular Disorders
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：26
- 期：6
- 页码：378-385
- 全文大小：1787 K
文摘
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SERCA impairment has been suggested to occur in DM and in hypothyroid myopathy.
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SERCA activity and expression of SERCA1 and SERCA2 are not altered in these patients.
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SERCA1b is expressed at protein level in DM2 and, in lower amount, in DM1 muscle.
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The reduction of SERCA activity might be specific for Brody myopathy.