Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)
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- 作者：Abdelselam Ali ; Marianne Bliese ; Jo-Anne M. Rasmussen ; Roger M. Sargent ; Simon Saubern ; David G. Sawutz ; John S. Wilkie ; David A. Winkler ; Kevin N. Winzenberg ; Ruth C.J. Woodgate
- 关键词：(Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile ; Parasiticide ; Haemonchus contortus ; Ctenocephalides felis (cat flea)
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 出版时间：15 February 2007
- 年：2007
- 卷：17
- 期：4
- 页码：993-997
- 全文大小：141 K
文摘
A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites.