Development of a Rational Design Space for Optimizing Mixing Conditions for Formation of Adhesive Mixtures for Dry-Powder Inhaler Formulations

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• 作者：Saurabh Sarkar¹ ; Bruna Minatovicz¹ ; Kyrre Thalberg³ ; Bodhisattwa Chaudhuri¹ ; ² ; ^{bodhi.chaudhuri@uconn.edu}
• 关键词：adhesive mixtures ; dry-powder inhalers ; press-on forces ; abrasion ; mixing ; pulmonary drug delivery
• 刊名：Journal of Pharmaceutical Sciences
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：106
• 期：1
• 页码：129-139
• 全文大小：2073 K
• 卷排序：106

文摘

The purpose of the present study was to develop guidance toward rational choice of blenders and processing conditions to make robust and high performing adhesive mixtures for dry-powder inhalers and to develop quantitative experimental approaches for optimizing the process. Mixing behavior of carrier (LH100) and AstraZeneca fine lactose in high-shear and low-shear double cone blenders was systematically investigated. Process variables impacting the mixing performance were evaluated for both blenders. The performance of the blenders with respect to the mixing time, press-on forces, static charging, and abrasion of carrier fines was monitored, and for some of the parameters, distinct differences could be detected. A comparison table is presented, which can be used as a guidance to enable rational choice of blender and process parameters based on the user requirements. Segregation of adhesive mixtures during hopper discharge was also investigated.