Cross talk between MMP2-Spm-Cer-S1P and ERK1/2 in proliferation of pulmonary artery smooth muscle cells under angiotensin II stimulation
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- 作者：Animesh Chowdhury ; Jaganmay Sarkar ; Pijush Kanti Pramanik ; Tapati Chakraborti ; Sajal Chakraborti ; sajal_chakraborti@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANG II ; NADPH oxidase ; proMMP-2 ; S1P ; Cell proliferation ; BPASMC
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：603
- 期：Complete
- 页码：91-101
- 全文大小：1951 K
文摘
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Angiotensin II induces an increase in proliferation of pulmonary artery smooth muscle cells.
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Angiotensin II-induced cell proliferation is mediated by Spm-Cer-S1P signaling pathway.
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MMP-2 plays an important role in the activation of Spm-Cer-S1P signaling pathway by angiotensin II.
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Angiotensin II induces an increase in NADPH oxidase derived O2•– which leads to the activation of proMMP-2 and ultimately causes cell proliferation.