Inhibition of MMP-9 by green tea catechins and prediction of their interaction by molecular docking analysis

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• 作者：Jaganmay Sarkar ^{sarkarjaganmay@gmail.com} ; Suman Kumar Nandy ^{bhramoman@gmail.com} ; Animesh Chowdhury¹ ; ^{animeshchowdhury9@gmail.com} ; Tapati Chakraborti ^{tcbiochem@gmail.com} ; Sajal Chakraborti ; ^{sajal_chakraborti@yahoo.com}
• 关键词：Green tea catechins ; MMP-9 ; ProMMP-9 ; PASMC ; Molecular docking
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：84
• 期：Complete
• 页码：340-347
• 全文大小：3937 K
• 卷排序：84

文摘

Green tea extracts inhibit pro-/active MMP-9 activities in BPASMCs. ECG and EGCG showed higher ability to inhibit pro-/active MMP-9 activities. Galloyl group of EGCG & ECG are responsible to inhibit pro-/active MMP-9 activities. In silico docking analyses support the experimental findings.