Anticoagulant activity of Moon jellyfish (Aurelia aurita) tentacle extract
详细信息 查看全文
- 作者：Akriti Rastogi ; Sumit Biswas ; Angshuman Sarkar ; Dibakar Chakrabarty
- 关键词：Moon jellyfish ; Anticoagulant ; Fibrinogenolytic toxin
- 刊名：Toxicon
- 出版年：2012
- 出版时间：October, 2012
- 年：2012
- 卷：60
- 期：5
- 页码：719-723
- 全文大小：405 K
文摘
Moon jellyfish (Aurelia aurita) tentacle extract was studied for its anticoagulant activity in?vitro. The Jellyfish Tentacle Extract (JFTE) showed very strong fibrinogenolytic activity by cleaving A¦Á and B¦Â chain of fibrinogen molecule. The fibrinogenolytic activity was found to be stronger than some snake venom derived anticoagulants. JFTE also completely liquefied fibrin clots in 24?h. JFTE was found to contain both high and low molecular weight proteins/peptides. The fibrinogenolysis appears to be caused by high molecular weight fractions of the extract. It has been also noted that PMSF significantly reduced fibrinogenolytic activity and heating totally abolished it. Autolytic degradation of the high molecular weight protein was also noted. Autolysis slowed down, but did not abolish the fibrinogenolytic activity of the extract.