Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, α-lipoic acid and α-tocopherol
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- 作者：Maitrayee Sinha1 ; Aritri Bir2 ; Anindita Banerjee2 ; Pritha Bhowmick ; Sasanka Chakrabarti ; 2 ; profschakrabarti95@gmail.com" class="auth_mail" title="E-mail the corresponding author ; s_chakrabarti54@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amyloid precursor protein ; β Secretase ; Neprilysin ; Amyloid beta protein ; Alzheimer's disease ; Antioxidant
- 刊名：Neurochemistry International
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：92-99
- 全文大小：1451 K
文摘
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Amyloid precursor protein accumulates in aged rat brain.
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β-secretase activity increases in aged brain.
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Activity of neprilysin decreases during brain aging in rats.
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Amyloid beta 42 accumulates in aged rat brain.
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All these are prevented by supplementation with nutraceuticals and antioxidants.