Job’s plot confirmed the 1:1 stoichiometry of the DMβCD/SASP inclusion complex.
FT-IR, NMR, PXRD, DSC, and SEM analysis confirmed the complex formation.
The DMβCD/SASP/CS NPs showed higher EE and LE than the SASP/CS NPs.
An obvious sustained-release manner of SASP was gained by the DMβCD/SASP/CS NPs.
The DMβCD/SASP/CS NPs exhibited lower toxic to LO2 cells than free SASP.