A single center's approach to discriminating donor versus host origin of renal neoplasia in the allograft kidney
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- 作者：Adam J. Robin ; M.D.a ; Eric P. Cohen ; M.D.b ; Tepsiri Chongkrairatanakul ; M.D.b ; Ehad Saad ; M.D.b ; A. Craig Mackinnon ; M.D. ; Ph.D.a ; amackinnon@mcw.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Renal cell carcinoma ; Allograft ; Malignancy ; Posttransplant malignancy ; Microsatellite analysis
- 刊名：Annals of Diagnostic Pathology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：23
- 期：Complete
- 页码：32-34
- 全文大小：168 K
文摘
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Determination of tumor cell origin is significant for staging and management of RCC in renal allografts.
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Genetic analysis, such as microsatellite analysis, should be use on a routine basis to determine the origin of RCC in the kidney allograft.
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Microsatellite analysis of the polymorphic Penta C and Penta D alleles is a convenient, robust, and efficient strategy to determine donor versus recipient origin of RCC in allograft kidney specimens.
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Confirmed donor derived malignancy should be reported to the live organ donor or allograft recipients, as surveillance for malignancy may be warranted.