Identification of a histone derived, putative antimicrobial peptide Himanturin from round whip ray Himantura pastinacoides and its phylogenetic significance
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- 作者：Naveen Sathyan ; Rosamma Philip ; rosammap@gmail.com ; rose@cusat.ac.in ; E.R. Chaithanya ; P.R. Anil Kumar ; Swapna P. Antony
- 关键词：Antimicrobial peptide ; Himantura pastinacoides ; Elasmobranch ; Histone H2A ; Himanturin
- 刊名：Results in Immunology
- 出版年：2012
- 出版时间：2012
- 年：2012
- 卷：2
- 期：Complete
- 页码：120-124
- 全文大小：574 K
文摘
Histone H2A participates in host defense responses by producing antimicrobial peptides (AMPs). The present study deals with identification of a putative antimicrobial sequence, Himanturin from the histone H2A of Round Whip Ray, Himantura pastinacoides. A 204 bp fragment encoding 68 amino acid residues was amplified from cDNA of Round Whip Ray, H. pastinacoides. Himanturin exhibited high similarity to previously reported histone H2A derived AMPs indicating the presence of an antimicrobial sequence motif. Physicochemical properties of Himanturin suggest it to be a potential antimicrobial candidate.