文摘
ESC expression of Ngn2/Isl1/Lhx3 induces rapid transcriptional and chromatin changes At early stages, Isl1/Lhx3 (homeodomain) and Ngn2 (bHLH) target distinct genomic sites As programming progresses, Isl1/Lhx3 binding shows dynamic relocalization Ngn2-induced factors guide Isl1/Lhx3 redistribution to initially inaccessible sites