Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with α2 integrin
详细信息 查看全文
- 作者：Francis Roche1 ; &dagger ; ; frank.roche@igp.uu.se" class="auth_mail" title="E-mail the corresponding author ; Kalle Sipilä ; 2 ; &dagger ; ; Satoshi Honjo1 ; Staffan Johansson3 ; Sò ; nia Tugues1 ; &Dagger ; ; Jyrki Heino2 ; &dagger ; ; Lena Claesson-Welsh1 ; &dagger ;
- 关键词：HRG ; histidine-rich glycoprotein ; HUVEC ; human umbilical cord endothelial cell ; EC ; endothelial cell ; COL I ; type I collagen ; HS ; heparan sulfate
- 刊名：Matrix Biology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：48
- 期：Complete
- 页码：89-99
- 全文大小：1137 K
文摘
- •
The plasma protein HRG inhibits endothelial cell adhesion, spreading and motility.
- •
HRG inhibits endothelial cell adhesion specifically to collagen I.
- •
HRG inhibits adhesion through low affinity interaction with a2 integrin, independent of heparan sulfate.
- •
HRG colocalizes with collagen and vessel-rich stroma in tumors.