Heating ability of La-Sr-Mn-Cu perovskite spheres under an alternating current magnetic field for magnetic hyperthermia mediators

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• 作者：Mayumi Horiki ; Takashi Nakagawa ; ^{nakagawa@mit.eng.osaka-u.ac.jp} ; Satoshi Seino ; Takao A. Yamamoto
• 关键词：La&ndash ; Sr&ndash ; Mn&ndash ; Cu perovskite ; Magnetic hyperthermia ; Curie temperature ; Temperature control ; Sphere
• 刊名：Journal of Magnetism and Magnetic Materials
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：329
• 期：Complete
• 页码：49-52
• 全文大小：454 K

文摘

La_0.666Sr_0.373Mn_0.943Cu_0.018O₃ spheres (average diameter: 2.4 mm) were used as magnetic hyperthermia mediators. They were prepared by the polymerized complex method and alginate gelation. A starch paste containing nine such spheres (0.1034 g) was maintained at a constant temperature when it was exposed to an alternating current magnetic field (frequency: 1 MHz; magnetic field strength: 20-55 Oe-rms). After exposure to a magnetic field with a field strength of 55 Oe-rms for 60 min, a temperature of T₆₀=73.5 ¡ãC was obtained. T₆₀ for field strengths of 40 and 55 Oe-rms differed by only 2.6 ¡ãC. La_0.666Sr_0.373Mn_0.943Cu_0.018O₃ spheres satisfy the following important requirements for heating mediators: their amount can be controlled in tumors, their temperature can be controlled without monitoring, and their heating ability is independent of the field strength and direction. Thus, La_0.666Sr_0.373Mn_0.943Cu_0.018O₃ spheres are promising heating mediators for inducing magnetic hyperthermia.