Magnetic resonance imaging of glutamate in neuroinflammation

详细信息    查看全文

• 作者：Y.Z. Chen^a ; ^b ; Z.Z. Dai^a ; ^b ; ^c ; Z.W. Shen^a ; ^b ; G.S. Lin^a ; ^b ; C.Y. Zhuang^a ; ^b ; H.J. Li^d ; ^{lihongjun00113@126.com" class="auth_mail" title="E-mail the corresponding author} ; R.H. Wu^a ; ^b ; ^{rhwu@stu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Glutamate ; GluCEST ; 1H-MRS ; Microglia ; Neuroinflammation
• 刊名：Radiology of Infectious Diseases
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：3
• 期：2
• 页码：92-97
• 全文大小：1078 K

文摘

Inflammation in central nervous system (CNS) is one of the most severe diseases, and also plays an impellent role in some neurodegenerative diseases. Glutamate (Glu) has been considered relevant to the pathogenesis of neuroinflammation. In order to diagnose neuroinflammation incipiently and precisely, we review the pathobiological events in the early stages of neuroinflammation, the interactions between Glu and neuroinflammation, and two kinds of magnetic resonance techniques of imaging Glu (chemical exchange saturation transfer and magnetic resonance spectroscopy).