Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation
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- 作者：Maria Luisa Panno ; Francesca Giordano ; Fabrizia Mastroianni ; M. Grazia Palma ; Viviana Bartella ; Amalia Carpino ; Saveria Aquila ; Sebastiano Andò
- 关键词：Bergapten ; Cell survival ; Apoptosis ; p53 ; p21/PCNA
- 刊名：FEBS Letters
- 出版年：2010
- 出版时间：3 June 2010
- 年：2010
- 卷：584
- 期：11
- 页码：2321-2326
- 全文大小：453 K
文摘
In this study we have reported that bergapten (B) and bergapten plus UV (PUVA) are able to significantly affect MCF-7, ZR-75 and SKBR-3 breast cancer cell proliferations.
B induced a lowering of PI3K/AKT survival signal in MCF-7 cells even in presence of IGF-I stimulation. Furthermore, B and in a higher extent, PUVA up-regulated the p53 mRNA and the protein content. An increased co-association between p21 WAF and proliferating cell nuclear antigen (PCNA) has been observed in PUVA-treated MCF-7 cells, thus inhibiting DNA replication. These results highlight how B, and its photoactivated compound, exert antiproliferative effects and induce apoptotic responses in breast cancer cells.