New developments in zinc-catalyzed asymmetric hydrosilylation of ketones with PMHS

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• 作者：Bette ; Virginie ; Mortreux ; André ; Savoia ; Diego ; Carpentier ; Jean-Franç ; ois
• 关键词：Asymmetric catalysis ; Diamines ; Hydrosilylation ; Ketones ; PMHS ; Zinc
• 刊名：Tetrahedron
• 出版年：2004
• 出版时间：March 15, 2004
• 年：2004
• 卷：60
• 期：12
• 页码：2837-2842
• 全文大小：208 K

文摘

The influence of structural modifications of the diamine ligand and the ZnR₂ precursor in the [ZnR₂–diamine]-catalyzed asymmetric hydrosilylation of prochiral ketones with PMHS in aprotic medium is reported. A new diamine ligand giving up to 91 % ee in the reduction of acetophenone is described. The scope of this reduction system has been investigated using variously functionalized ketones and some deactivation pathways have been identified.