Autophagy inhibition upregulates CD4⁺ tumor infiltrating lymphocyte expression via miR-155 regulation and TRAIL activation

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• 作者：Paul Zarogoulidis^a ; Savvas Petanidis^b ; ^{spetanid@auth.gr} ; Kalliopi Domvri^a ; Efrosini Kioseoglou^b ; Doxakis Anestakis^c ; ^d ; Lutz Freitag^e ; Konstantinos Zarogoulidis^a ; Wolfgang Hohenforst-Schmidt^f ; Wilfried Eberhardt^g
• 关键词：Lung cancer ; Chemoresistance ; Tumor infiltrating lymphocytes ; miR-155 ; TRAIL
• 刊名：Molecular Oncology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：10
• 期：10
• 页码：1516-1531
• 全文大小：3445 K
• 卷排序：10

文摘

Blockage of autophagy increases lung cancer chemosensitivity to carboplatin. Autophagy inhibition triggers upregulation of Foxp3+ and CD4+ TILs. Targeting of autophagy elucidates immune T cell infiltration. Autophagic inhibition promotes reduction in the expression of drug resistance genes. MiR-155 functions as a novel immune system activator by promoting TILs infiltration.