Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment

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• 作者：Sayaka Sekiya¹ ; ³ ; Shizuka Miura¹ ; ³ ; Kanae Matsuda-Ito¹ ; ³ ; Atsushi Suzuki¹ ; ² ; ^{suzukicks@bioreg.kyushu-u.ac.jp}
• 关键词：liver ; progenitor cell ; myofibroblast ; tumor microenvironment
• 刊名：Stem Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：7
• 期：6
• 页码：1130-1139
• 全文大小：3834 K
• 卷排序：7

文摘

HPCs isolated from the chronically injured liver can give rise to myofibroblasts The frequency of myofibroblast production from HPCs is low in culture HPCs can give rise to a number of myofibroblasts during tumor development HPCs themselves can contribute to the formation of the tumor microenvironment