Early alterations of mitochondrial morphology in dopaminergic neurons from Parkinson's disease-like pathology and time-dependent neuroprotection with D2 receptor activation
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- 作者：Lyle Wiemerslagea ; lyle.wiemerslage@neuro.uu.se" class="auth_mail" title="E-mail the corresponding author ; Sazan Ismaelb ; Daewoo Leeb
- 关键词：Mitochondria ; Cell culture ; Drosophila ; Parkinson ; Dopamine ; Morphology
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：138-147
- 全文大小：1125 K
文摘
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PD-like treatment changes several parameters of mitochondrial morphology.
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Changes in mitochondrial morphology are an early event in the death of DA neurons.
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D2R agonists must be added concomitantly with PD-like insult to be neuroprotective.