Synthesis and anti-inflammatory activity of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives
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- 作者：Jakubkiene ; Virginija ; Burbuliene ; Milda Malvina ; Meku&scaron ; kiene ; Giedrute ; Udrenaite ; Emilija ; et. al.
- 关键词：1 ; 3 ; 4-Oxadiazole-2-thiones ; Aminomethylation ; Anti-inflammatory activity
- 刊名：Il Farmaco
- 出版年：2003
- 出版时间：April, 2003
- 年：2003
- 卷：58
- 期：4
- 页码：323-328
- 全文大小：128 K
文摘
The synthesis of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-2,3-dihydro-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives and the results of anti-inflammatory activity in vivo are described. Most of the tested compounds exhibited anti-inflammatory activity and some of them were more active than acetylsalicylic acid.