Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon

详细信息    查看全文

• 作者：Sa&scaron ; a R. Ivanović^a ; ^{si34826@gmail.com} ; Blagoje Dimitrijević^b ; Vitomir Ćupić^a ; Milanka Jezdimirović^a ; Sunčica Borozan^c ; Mila Savić^d ; Djordje Savić^e
• 关键词：Diazinon (PubChem CID ; 3017) ; Mecamylamine hydrochloride (PubChem CID ; 13221) ; Pancuronium bromide (PubChem CID ; 27350) ; Atropine sulfate monohydrate (PubChem CID ; 64663)
• 刊名：Toxicology Reports
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：3
• 期：Complete
• 页码：523-530
• 全文大小：950 K
• 卷排序：3

文摘

We studied the development of tolerance to subchronic p.o. administration of DZN in rats, under both in vivo and in vitro conditions As a consequence of AChE inhibition, ACh neurotransmitters are being accumulated in over stimulated nicotinic and muscarinic receptors. With isolated diaphragm and ileum, we examined the down regulation of nicotinic and muscarinic receptor function through EFS technique. The results of our research could be useful in forensic diagnostics of organophosphate poisoning.