Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships
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- 作者：Rita A. Sakra ; Michail Schizasa ; Jose V. Scarpa Carnielloa ; Charlotte K.Y. Ngb ; Salvatore Piscuogliob ; Dilip Girib ; Victor P. Andradea ; Marina De Brota ; Raymond S. Limb ; Russell Towersa ; Britta Weigeltb ; Jorge S. Reis-Filhob ; c ; 1 ; reisfilj@mskcc.org" class="auth_mail" title="E-mail the corresponding author ; Tari A. Kinga ; 1 ; tking7@partners.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Massively parallel sequencing ; Invasive lobular carcinoma ; Lobular carcinoma in situ ; Clonality ; Somatic genetic alterations
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：10
- 期：2
- 页码：360-370
- 全文大小：704 K
文摘
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LCIS and invasive lobular carcinoma have a similar repertoire of somatic mutations.
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<em>PIK3CAem> and <em>CDH1em> are the most frequently mutated genes in this setting.
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LCIS is a non-invasive clonal neoplastic lesion.
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LCIS may act as a non-obligate precursor of invasive lobular carcinoma.