How do macrophages sense modified low-density lipoproteins?

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• 作者：Dimitry A. Chistiakov^a ; Alexandra A. Melnichenko^b ; Alexander N. Orekhov^b ; ^c ; Yuri V. Bobryshev^b ; ^c ; ^d ; ^e ; ^{y.bobryshev@mail.ru}
• 关键词：Modified LDL ; Macrophage ; Atherosclerosis ; Scavenger receptor ; Toll-like receptor ; Foam cell formation
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：230
• 期：Complete
• 页码：232-240
• 全文大小：1075 K
• 卷排序：230

文摘

Macrophages are capable of recognizing and binding foreign or altered-self targets. Modified LDL can be sensed and taken up by macrophages with a battery of scavenger receptors. In atherosclerosis, lipid balance is deregulated that induces the inability of macrophages to completely recycle modified LDL.