The Glomerular Barrier Fits a Two-Pore-and-Fiber-Matrix Model: Derivation and Physiologic Test

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• 作者：Katz ; Murray A. ; Schaeffer Jr ; Richard C. ; Gratrix ; Max ; Mucha ; David ; Cá ; rbajal ; José
• 刊名：Microvascular Research
• 出版年：1999
• 出版时间：May, 1999
• 年：1999
• 卷：57
• 期：3
• 页码：227-243
• 全文大小：141 K

文摘

Failure of the glomerular barrier causing proteinuria has been modeled chiefly by Chang, Deen, and Brenner. They have refined models from an isoporous filter to a mostly isoporous membrane, which during proteinuric disease opens up nondiscriminating shunts. This report extends these concepts by measuring a larger distribution of macromolecular tracer sizes and bringing in a fiber matrix. By clearance methods, glomerular sieving curves of relatively neutral tetramethyl rhodamine aminodextran from radii of 15 to over 80 Å were obtained and fitted to theory. Two pores filled with matrix fit all data without exception, and no other model did. Five parameters described the curve in control rats and in proteinuric rats made so by albumin injections. From highest to lowest degree of confidence, these were small and large pore radiir_os