P 187. Tinnitus-related neuroplastic alterations in the motor cortex

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• 作者：M. Schecklmann ; E. Frank ; T. Kleinjung ; M. L ; grebe ; B. Langguth
• 刊名：Clinical Neurophysiology
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：124
• 期：10
• 页码：e153
• 全文大小：37 K

文摘

Introduction

Chronic tinnitus is a brain network disorder with involvement of auditory and non-auditory areas motivating the clinical use of repetitive transcranial magnetic stimulation (rTMS). Several small studies indicated that motor cortex excitability is altered in tinnitus. Furthermore, motor cortex excitability was changed according to treatment response of rTMS of auditory cortex.

Objectives

Here, we aimed to investigate motor cortex excitability before and after rTMS of auditory cortex.

Materials and methods

We investigated 231 patients with chronic tinnitus and 120 healthy controls in a retrospective manner pooling data from different studies. Variables of interest were resting motor threshold (RMT), short-interval intra-cortical inhibition (SICI), intracortical facilitation (ICF), and cortical silent period (CSP). 118 patients were tested twice-at the first and last day of treatment with temporal oriented rTMS. Treatment response was defined as five-point change in tinnitus questionnaire.

Results

Tinnitus was associated with increased motor inhibition (SICI, CSP) and facilitation (ICF). Successful treatment response was associated with normalisation of increased SICI.

Conclusion

Our data suggest that altered SICI may reflect a state parameter, whereas CSP and ICF may rather mirror a trait-like predisposing factor of tinnitus.