NF-κB and the innate immune response

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• 作者：Hatada ; Eunice N ; Krappmann ; Daniel ; Scheidereit ; Claus
• 关键词：Immunology ; Biochemistry ; NF-κ ; B ; Innate immunity ; Cell signalling ; Cell development ; Cell survival
• 刊名：Current Opinion in Immunology
• 出版年：2000
• 出版时间：February 1, 2000
• 年：2000
• 卷：12
• 期：1
• 页码：52-58
• 全文大小：105 K

文摘

In the innate immune reaction, microbial pathogens activate phylogenetically conserved cellular signal transduction pathways that regulate the ubiquitous nuclear factor-κB (NFκB). NF-κB has pleiotropic functions in immunity; however, it is also critical for development and cellular survival. Many aspects of how the different pathways utilize a common kinase complex that ultimately activates NF-κB have been clarified by gene inactivation and biochemical analysis.