A Dual Role for Ikkα in Tooth Development

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• 作者：Atsushi Ohazama ; Yinling Hu ; Ruth Schmidt-Ullrich ; Yixue Cao ; Claus Scheidereit ; Michael Karin ; Paul T. Sharpe
• 关键词：CELLBIO ; CELLCYCLE
• 刊名：Developmental Cell
• 出版年：2004
• 出版时间：February 2004
• 年：2004
• 卷：6
• 期：2
• 页码：219-227
• 全文大小：1039 K

文摘

IKKα is a component of the IκB kinase (IKK) complex that plays a key role in the activation of NF-κB. In Ikkα mutant mice and mice expressing a transdominant negative mutant of IκBα (c^IκBαΔN), molars have abnormal cusps, indicating that Ikkα is involved in cusp formation through the NF-κB pathway. However, Ikkα mutant incisors also have an earlier phenotype where epithelium evaginates outward into the developing oral cavity rather than invaginating into the underlying mesenchyme. A similar evagination of epithelium was also observed in whisker development, suggesting that Ikkα contributes to the direction of epithelial growth during the early stages of development in many ectodermal appendages. Since c^IκBαΔN mice have normal incisor epithelial invagination, Ikkα's role appears to be NF-κB independent. Changes in Notch1, Notch2, Wnt7b, and Shh expression found in incisor epithelium of Ikkα mutants suggest that this NF-κB-independent function is mediated by Notch/Wnt/Shh signaling pathways.